abstract：:Outbred rat lines such as Wistar rats are commonly used for models of depressive disorders. Such rats arise from random mating schedules. Hence, genetic drift occurs in outbred populations which could lead to genotypic and phenotypic heterogeneity between rats from different vendors. Additionally, vendor specific rear...

journal_title：Brain research

authors： Theilmann W,Kleimann A,Rhein M,Bleich S,Frieling H,Löscher W,Brandt C

更新日期：2016-07-01 00:00:00

abstract：:Hirschsprung's disease (HSCR) is a congenital malformation characterized by the absence of enteric ganglia in the distal intestine and gut obstruction. Some HSCR patients also have associated neurological symptoms. We studied a rat model of HSCR, also known as spotting lethal (sl/sl) rat, which carries a spontaneous d...

journal_title：Brain research

authors： Xie D,Croaker GDH,Li J,Song ZM

更新日期：2016-07-01 00:00:00

abstract：:The present study investigated the antidepressant potential of curcumin in olfactory bulbectomy and forced swimming test models of depression in male albino rats under chronic treatment. The experimental animals were divided into four groups, and curcumin was administered for 45 days. Our results showed that the curcu...

journal_title：Brain research

authors： Chang XR,Wang L,Li J,Wu DS

更新日期：2016-07-01 00:00:00

abstract：:To determine whether post-traumatic seizure severity would be affected by the interval between seizures and head injury, we measured seizures after various times with or without fluid percussion brain injury (2atm fluid percussion injury; FPI). To determine efficacy of anti-seizure medication, we also determined if le...

journal_title：Brain research

authors： Chen YH,Huang EY,Kuo TT,Hoffer BJ,Wu PJ,Ma HI,Tsai JJ,Chou YC,Chiang YH

更新日期：2016-07-01 00:00:00

abstract：:While genetic predisposition is a major factor, it is not known how development of attention-deficit/hyperactivity disorder (ADHD) is modulated by early life stress. The spontaneously hypertensive rat (SHR) displays the behavioral characteristics of ADHD (poorly sustained attention, impulsivity, hyperactivity) and is ...

journal_title：Brain research

authors： Sterley TL,Howells FM,Russell VA

更新日期：2016-06-15 00:00:00

abstract：:Myelin is probably one of the most fascinating and innovative biological acquisition: a glia plasma membrane tightly wrapped around an axon and insulating it. Chondrichthyans (cartilaginous fishes) form a large group of vertebrates, and they are among oldest extant jawed vertebrate lineage. It has been known from stud...

journal_title：Brain research

authors： de Bellard ME

更新日期：2016-06-15 00:00:00

abstract：:Myelin, the lipid-rich sheath that insulates axons to facilitate rapid conduction of action potentials, is an evolutionary innovation of the jawed-vertebrate lineage. Research efforts aimed at understanding the molecular mechanisms governing myelination have primarily focused on rodent models; however, with the advent...

journal_title：Brain research

authors： Ackerman SD,Monk KR

更新日期：2016-06-15 00:00:00

abstract：:Noradrenergic neurons of the brainstem extend projections throughout the neuraxis to modulate a wide range of processes including attention, arousal, autonomic control and sensory processing. A spinal projection from the locus coeruleus (LC) is thought to regulate nociceptive processing. To characterize and selectivel...

journal_title：Brain research

authors： Li Y,Hickey L,Perrins R,Werlen E,Patel AA,Hirschberg S,Jones MW,Salinas S,Kremer EJ,Pickering AE

更新日期：2016-06-15 00:00:00

abstract：:Dorsal temporal pole (dTP) is a cortical region at the rostral end of the superior temporal gyrus that forms part of the ventral auditory object processing pathway. Anatomical connections with frontal and medial temporal areas, as well as a recent single-unit recording study, suggest this area may be an important part...

journal_title：Brain research

authors： Bigelow J,Ng CW,Poremba A

更新日期：2016-06-01 00:00:00

abstract：:Auditory working memory (WM) is the cognitive faculty that allows us to actively hold and manipulate sounds in mind over short periods of time. We develop here a particular perspective on WM for non-verbal, auditory objects as well as for time based on the consideration of possible parallels to visual WM. In vision, t...

journal_title：Brain research

authors： Joseph S,Teki S,Kumar S,Husain M,Griffiths TD

更新日期：2016-06-01 00:00:00

abstract：:Among the many pathophysiologic consequences of traumatic brain injury are changes in catecholamines, including dopamine, epinephrine, and norepinephrine. In the context of TBI, dopamine is the one most extensively studied, though some research exploring epinephrine and norepinephrine have also been published. The pur...

journal_title：Brain research

authors： Osier ND,Dixon CE

更新日期：2016-06-01 00:00:00

abstract：:Early adverse events have been shown to increase the incidence of interstitial cystitis/painful bladder syndrome in adulthood. Despite high clinical relevance and reports of stress-related symptom exacerbation, animal models investigating the contribution of early life stress to female urological pain are lacking. We ...

journal_title：Brain research

authors： Pierce AN,Di Silvestro ER,Eller OC,Wang R,Ryals JM,Christianson JA

更新日期：2016-05-15 00:00:00

abstract：:A neuron׳s response to a sound can be suppressed by the presentation of a preceding sound. It has been suggested that this suppression is a direct correlate of the psychophysical phenomenon of forward masking, however, forward suppression, as measured in the responses of the auditory nerve, was insufficient to account...

journal_title：Brain research

authors： Ingham NJ,Itatani N,Bleeck S,Winter IM

更新日期：2016-05-15 00:00:00

abstract：:Ion channels are integral membrane proteins that allow passive diffusion of ions across membranes. In neurons and in other excitable cells, the harmonious coordination between the numerous types of ion channels shape and propagate electrical signals. Increased accumulation of reactive oxidative species (ROS), and subs...

journal_title：Brain research

authors： Patel R,Sesti F

更新日期：2016-05-15 00:00:00

abstract：:Oligodendrocyte precursor cells (OPCs) react rapidly to brain and spinal cord injuries. This reaction is characterized by the retraction of cell processes, cell body swelling and increased expression of the NG2 chondroitin sulfate proteoglycan. Reactive OPCs rapidly divide and accumulate surrounding the injury site wh...

journal_title：Brain research

authors： Levine J

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of salvinorin A (SA) on brain injury and neurologic function post-brain ischemia/reperfusion (I/R) using a rat forebrain ischemia model and further explore the effect of kappa opioid receptor (KOR) inhibition by SA on aquaporin-4 (AQP4) expression in the hippocampus, cortex and stria...

journal_title：Brain research

authors： Xin J,Zhang Y,He Z,Wang Z

更新日期：2016-04-15 00:00:00

abstract：:Brain injury accelerates amyloid-β (Aβ) deposits and exacerbates Alzheimer's disease (AD). Accumulation of intracellular soluble Aβ impairs cognition prior to emergence of Aβ plaques. However, it is not known whether brain injury affects learning impairment attributable to intracellular soluble Aβ. We made a small inj...

journal_title：Brain research

authors： Zou J,Wang M,Uchiumi O,Shui Y,Ishigaki Y,Liu X,Tajima N,Akai T,Iizuka H,Kato N

更新日期：2016-04-15 00:00:00

abstract：:Recently it has been reported that prolactin (PRL) exerts a neuroprotective effect against excitotoxicity in hippocampus in the rat in vivo models. However, the exact mechanism by which PRL mediates this effect is not completely understood. The aim of our study was to assess whether prolactin exerts neuroprotection ag...

journal_title：Brain research

authors： Vergara-Castañeda E,Grattan DR,Pasantes-Morales H,Pérez-Domínguez M,Cabrera-Reyes EA,Morales T,Cerbón M

更新日期：2016-04-01 00:00:00

abstract：:In auditory speech processing, phonological stress functions as an attention holding cue, which facilitates detection of mispronunciations and phonetic deviants in strong syllables as compared to weak ones. Whereas silent reading involves activation of phonological information including word stress, it is not clear wh...

journal_title：Brain research

authors： Kriukova O,Mani N

更新日期：2016-04-01 00:00:00

abstract：:Investigations of the time course of various stages of lexical processing have indicated either early or late onset of brain activation for phonological code retrieval. The basis of the differential findings is unclear, but factors related to segmental phonology appear to be part of it. The purpose of the present stud...

journal_title：Brain research

authors： Cummings A,Seddoh A,Jallo B

更新日期：2016-03-15 00:00:00

abstract：:We screened anti-Aβ1-42 antibodies from a human Alzheimer's disease (AD) specific single chain variable fragment (scFv) phage display library and assessed their effects in APP/PS1 transgenic mice. Reverse transcription-PCR was used to construct the scFv phage display library, and screening identified 11A5 as an anti-A...

journal_title：Brain research

authors： Wang J,Li N,Ma J,Gu Z,Yu L,Fu X,Liu X,Wang J

更新日期：2016-03-15 00:00:00

abstract：:In order to improve clinical trial design and translation of normobaric oxygen (NBO) treatment of ischemic stroke, NBO treatment parameters need to be better understood. This study investigated NBO treatment efficacy at two different stroke severities and two NBO treatment durations in rats. For the 60-min middle cere...

journal_title：Brain research

authors： Tiwari YV,Jiang Z,Sun Y,Du F,Rodriguez P,Shen Q,Duong TQ

更新日期：2016-03-15 00:00:00

abstract：:The ability to detect moving objects is crucial for survival and is a basic capability in the animal kingdom. In the optic tectum, a major center of the visual pathway of birds, neurons have been found that seem to be perfectly suited to encode motion. These cells, located in the stratum griseum centrale, receive a di...

journal_title：Brain research

authors： Verhaal J,Luksch H

更新日期：2016-03-15 00:00:00

abstract：:Spinal cord injury (SCI) often results in some form of paralysis. Recently, SCI therapy has been focused on preventing secondary injury to reduce both neuroinflammation and lesion size so that functional outcome after an SCI may be improved. Previous studies have shown that adenosine receptors (AR) are a major regulat...

journal_title：Brain research

authors： Yang CC,Jou IM

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Hypoxia is a critical secondary injury mechanism in traumatic brain injury (TBI), and early intervention to alleviate post-TBI hypoxia may be beneficial. NVX-108, a dodecafluoropentane perfluorocarbon, was screened for its ability to increase brain tissue oxygen tension (PbtO2) when administered soon after T...

journal_title：Brain research

authors： Mullah SH,Saha BK,Abutarboush R,Walker PB,Haque A,Arnaud FG,Hazzard B,Auker CR,McCarron RM,Scultetus AH,Moon-Massat P

更新日期：2016-03-01 00:00:00

abstract：:Animal and cell experiments showed that inositol hexaphosphate (IP6) was protective on neurons in parkinson's disease (PD) model, but the underlying mechanism of this action was not extensively elucidated. To address this question, we established 6-hydroxydopamine (6-OHDA) induced human dopaminergic cell line SH-SY5Y ...

journal_title：Brain research

authors： Zhang Z,Hou L,Li X,Ju C,Zhang J,Li X,Wang X,Liu C,Lv Y,Wang Y

更新日期：2016-02-15 00:00:00

abstract：:Explicit memory is widely assumed to reflect the conscious processes of recollection and familiarity. However, familiarity has been hypothesized to be supported by nonconscious processing. In the present functional magnetic resonance imaging (fMRI) experiment, we assessed whether familiarity is mediated by some of the...

journal_title：Brain research

authors： Thakral PP,Kensinger EA,Slotnick SD

更新日期：2016-02-01 00:00:00

abstract：:The current experiment aimed to explore age differences in brain activity associated with successful memory retrieval in older adults with different levels of executive functioning, at different levels of task demand. Memory performance and fMRI activity during a recognition task were compared between a young group an...

journal_title：Brain research

authors： Angel L,Bastin C,Genon S,Salmon E,Fay S,Balteau E,Maquet P,Luxen A,Isingrini M,Collette F

更新日期：2016-01-15 00:00:00

abstract：:Mammalian transglutaminases (TGs) catalyze the irreversible post-translational modifications of proteins, the most prominent of which is the calcium-dependent formation of covalent acyl transfers between the γ-carboxamide group of glutamine and the ε-amino-group of lysine (GGEL-linkage). In the central nervous system,...

journal_title：Brain research

authors： Schulze-Krebs A,Canneva F,Schnepf R,Dobner J,Dieterich W,von Hörsten S

更新日期：2016-01-15 00:00:00

abstract：:Chronic hydrocephalus is one of the severe complications after subarachnoid hemorrhage (SAH). However, there is no efficient treatment for the prevention of chronic hydrocephalus, partially due to poor understanding of underlying pathogenesis, subarachnoid fibrosis. Transforming growth factor-β1(TGF-β1) is a potent fi...

journal_title：Brain research

authors： Yan H,Chen Y,Li L,Jiang J,Wu G,Zuo Y,Zhang JH,Feng H,Yan X,Liu F

更新日期：2016-01-01 00:00:00

abstract：:Increasing evidences show that hippocampal synaptic plasticity plays a crucial role in the pathogenesis of depression. The objective of this study was to determine whether electroacupuncture (EA) in the Wistar Kyoto (WKY) rat model of depression would exert antidepressant effects and whether this effect would be assoc...

journal_title：Brain research

authors： She Y,Xu J,Duan Y,Su N,Sun Y,Cao X,Lao L,Zhang R,Xu S

更新日期：2015-12-10 00:00:00

abstract：:A central component of Attention Deficit Hyperactivity Disorder (ADHD) is increased distractibility in response to visual and auditory stimuli, which is linked to the superior colliculus (SC). Furthermore, there is now mounting evidence of altered collicular functioning in ADHD and it is proposed that a hyper-responsi...

journal_title：Brain research

authors： Brace LR,Kraev I,Rostron CL,Stewart MG,Overton PG,Dommett EJ

更新日期：2015-12-10 00:00:00

abstract：:In vitro assays offer a means of screening potential therapeutics and accelerating the drug development process. Here, we utilized neuronal cultures on planar microelectrode arrays (MEA) as a functional assay to assess the neurotoxicity of amyloid-β 1-42 (Aβ42), a biomolecule implicated in the Alzheimer׳s disease (AD)...

journal_title：Brain research

authors： Charkhkar H,Meyyappan S,Matveeva E,Moll JR,McHail DG,Peixoto N,Cliff RO,Pancrazio JJ

更新日期：2015-12-10 00:00:00

abstract：:Enriched environment (EE) has been shown to have beneficial effects on cognitive recovery after brain injury. Typical EE comprises three components: (i) enlarged living area providing physical activation, (ii) sensory stimulation, and (iii) social stimulation. The present study assessed the specific contribution of th...

journal_title：Brain research

authors： Gajhede Gram M,Gade L,Wogensen E,Mogensen J,Malá H

更新日期：2015-12-10 00:00:00

abstract：:Acute and repeated exposure to cocaine induces long-lasting alterations in neural networks that underlie compulsive drug seeking and taking. Cocaine exposure triggers complex adaptations in the brain that are mediated by dynamic patterns of gene expression that are translated into enduring changes. Recently, epigeneti...

journal_title：Brain research

authors： Sadri-Vakili G

更新日期：2015-12-02 00:00:00

abstract：:Drug addiction is characterized by persistent relapse vulnerability during abstinence. In abstinent drug users, relapse is often precipitated by re-exposure to environmental contexts that were previously associated with drug use. This clinical scenario is modeled in preclinical studies using the context-induced reinst...

journal_title：Brain research

authors： Marchant NJ,Kaganovsky K,Shaham Y,Bossert JM

更新日期：2015-12-02 00:00:00

abstract：:It is widely believed that substance use disorder (SUD) results from both pre-alterations (vulnerability) and/or post-alterations (drug effects) on cortico-striatal circuits. These circuits are essential for cognitive control, motivation, reward dependent learning, and emotional processing. As such, dysfunctions in co...

journal_title：Brain research

authors： Kravitz AV,Tomasi D,LeBlanc KH,Baler R,Volkow ND,Bonci A,Ferré S

更新日期：2015-12-02 00:00:00

abstract：:The rapidly evolving science of epigenetics is transforming our understanding of the nervous system in health and disease and holds great promise for the development of novel diagnostic and therapeutic approaches targeting neurological diseases. Increasing evidence suggests that epigenetic factors and mechanisms serve...

journal_title：Brain research

authors： Qureshi IA,Mehler MF

更新日期：2015-12-02 00:00:00

abstract：BACKGROUND:Chronic exposure to estradiol-17β (E2) in adult female rats increases mean arterial pressure by stimulating superoxide production in the rostral ventrolateral medulla (RVLM). However the mechanisms behind this phenomenon are unknown. We hypothesized that E2 exposure induces the gene expression of cytokines, ...

journal_title：Brain research

authors： Subramanian M,Hahn-Townsend C,Clark KA,MohanKumar SM,MohanKumar PS

更新日期：2015-11-19 00:00:00

abstract：:Endoplasmic reticulum (ER) and mitochondria dysfunction contribute to insulin resistance generation during obesity and diabetes. ER and mitochondria interact through Mitofusin 2 (MTF2), which anchors in the outer mitochondrial and ER membranes regulating energy metabolism. Ablation of MTF2 leads to ER stress activatio...

journal_title：Brain research

authors： Diaz B,Fuentes-Mera L,Tovar A,Montiel T,Massieu L,Martínez-Rodríguez HG,Camacho A

更新日期：2015-11-19 00:00:00